When the computer is finished, you can add your next disc.
Then you wait for the computer to put it's disc. The disc falls to the lowest empty slot in that column. Click on the column you want your disc to fall down into. Depending on what level you selected, either you starts (with red discs) or the computer starts (with yellow discs). The rules are simple: You play against the computer and you both have 21 discs (or markers) each.